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The rash also exhibits the following traits: It isnt itchy or painful but can be warm to the touch Usually begins at the location of the bite but may occur elsewhere with the spread of the bacteria Usually starts as a tiny red spot that enlarges over several days, eventually reaching a diameter of 30 centimeters or 12 inches Can lose color in the middle, causing a bulls-eye appearance The rash can be less noticeable on darker skin

Are There Standardized Dose-response Studies in Humans